1. Let's start by stating the problem: We need to simplify the expression before applying values $x_0$ and $x_1$. 2. The general rule is to simplify algebraic expressions first to make substitution easier and reduce errors. 3. Suppose the expression is $f(x) = ax^2 + bx + c$. We first simplify any like terms or factor if possible. 4. After simplification, we substitute $x_0$ and $x_1$ into the simplified expression to find $f(x_0)$ and $f(x_1)$. 5. This approach ensures clarity and correctness in evaluating the expression at given points. Therefore, yes, it is best to simplify the expression first before applying $x_0$ and $x_1$.