1. **State the problem:** We need to determine which numbers among 109, 80, 281, 16, 382, and 308 have 4 as a factor. 2. **Recall the rule for factors:** A number $a$ is a factor of another number $b$ if $b$ is divisible by $a$ without any remainder. In other words, $b \div a$ must be an integer. 3. **Check each number for divisibility by 4:** - For 109: Calculate $109 \div 4 = 27.25$, which is not an integer, so 4 is not a factor. - For 80: Calculate $80 \div 4 = 20$, which is an integer, so 4 is a factor. - For 281: Calculate $281 \div 4 = 70.25$, not an integer, so 4 is not a factor. - For 16: Calculate $16 \div 4 = 4$, an integer, so 4 is a factor. - For 382: Calculate $382 \div 4 = 95.5$, not an integer, so 4 is not a factor. - For 308: Calculate $308 \div 4 = 77$, an integer, so 4 is a factor. 4. **Final answer:** The numbers that have 4 as a factor are 80, 16, and 308.