1. The problem is to subtract the numbers 34 from 22, i.e., calculate $22 - 34$. 2. The subtraction formula is $a - b$, where $a$ and $b$ are numbers. 3. Here, $a = 22$ and $b = 34$. Since $b$ is greater than $a$, the result will be negative. 4. Perform the subtraction: $$22 - 34 = -(34 - 22) = -12$$ 5. Therefore, the final answer is $-12$.