Subjects pharmacology

Drug Dosage 5Acd3F

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1. **State the problem:** A 35-kg patient needs a drug dosage of 47 mg/kg/day. The drug is available as 300 mg tablets and a 200 mg per 5 mL suspension. We need to find: a. How many tablets the patient should take every 4 hours. b. The flow rate in gtt/hr for intravenous delivery over 12 hours with a drop factor of 10 gtt/mL. 2. **Calculate total daily dosage:** Total dosage per day = $47 \times 35 = 1645$ mg/day. 3. **Part a: Tablets every 4 hours** There are 24 hours in a day, so doses every 4 hours means $\frac{24}{4} = 6$ doses per day. Dosage per dose = $\frac{1645}{6} \approx 274.17$ mg per dose. Each tablet contains 300 mg, so tablets per dose = $\frac{274.17}{300} \approx 0.9139$ tablets. Since partial tablets are not practical, the patient should take 1 tablet every 4 hours. 4. **Part b: Flow rate in gtt/hr** Total volume of suspension needed per day: Concentration = 200 mg per 5 mL, so mg per mL = $\frac{200}{5} = 40$ mg/mL. Volume needed per day = $\frac{1645}{40} = 41.125$ mL. The drug is delivered over 12 hours, so flow rate in mL/hr = $\frac{41.125}{12} \approx 3.427$ mL/hr. Drop factor = 10 gtt/mL, so flow rate in gtt/hr = $3.427 \times 10 = 34.27$ gtt/hr. **Final answers:** a. 1 tablet every 4 hours. b. Approximately 34 gtt/hr flow rate.