Subjects pharmacology

Drug Dosage 9Bc64B

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1. **State the problem:** A 30-kg patient needs a drug dosage of 45 mg/kg/day. The drug is available as 500 mg tablets and a 200 mg/5 mL suspension. We need to find: (a) How many tablets the patient should take every 4 hours. (b) The intravenous flow rate in gtt/hr using the suspension with a drop factor of 10 gtt/mL over 12 hours. 2. **Calculate total daily dosage:** Total dosage per day = $45 \times 30 = 1350$ mg/day. 3. **(a) Tablets every 4 hours:** There are 24 hours in a day, so doses every 4 hours means $\frac{24}{4} = 6$ doses per day. Dosage per dose = $\frac{1350}{6} = 225$ mg per dose. Each tablet contains 500 mg, so tablets per dose = $\frac{225}{500} = 0.45$ tablets. 4. **(b) Flow rate in gtt/hr:** Total dosage per day = 1350 mg. Suspension concentration = 200 mg per 5 mL, so volume needed per day = $\frac{1350}{200} \times 5 = 33.75$ mL. Infusion time = 12 hours. Flow rate in mL/hr = $\frac{33.75}{12} = 2.8125$ mL/hr. Drop factor = 10 gtt/mL. Flow rate in gtt/hr = $2.8125 \times 10 = 28.125$ gtt/hr. **Final answers:** (a) 0.45 tablets every 4 hours. (b) Approximately 28 gtt/hr.